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nonlinear curve-fitting computer program sigmaplot  (SYSTAT)


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    SYSTAT nonlinear curve-fitting computer program sigmaplot
    Nonlinear Curve Fitting Computer Program Sigmaplot, supplied by SYSTAT, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/nonlinear+curve+fitting+computer+program/nonlinear+curve+fitting+computer+program+sigmaplot/pm25771452-58-48-52
    Average 90 stars, based on 1 article reviews
    nonlinear curve-fitting computer program sigmaplot - by Bioz Stars, 2026-11
    90/100 stars

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    other:

    Article Title: Transpiration of urban forests in the Los Angeles metropolitan area.
    Article Snippet: Despite its importance for urban planning, landscape management, and water management, there are very few in situ estimates of urban-forest transpiration.. Because urban forests contain an unusual and diverse mix of species from many regions worldwide, we hypothesized that species composition would be a more important driver of spatial variability in urban-forest transpiration than meteorological variables in the Los Angeles (California, USA) region.. We used constant-heat sap-flow sensors to monitor urban tree water use for 15 species at six locations throughout the Los Angeles metropolitan area.

    Article Title: Metabolic Drug-Drug Interaction Potential of Macrolactin A and 7- O -Succinyl Macrolactin A Assessed by Evaluating Cytochrome P450 Inhibition and Induction and UDP-Glucuronosyltransferase Inhibition In Vitro
    Article Snippet: The concentration required to inhibit enzyme activity by 50% (IC 50 ) was calculated using nonlinear curve fitting with SigmaPlot (version 8.0; Systat Software, Inc.).

    Article Title: Functional Studies of Tyrosine Hydroxylase Missense Variants Reveal Distinct Patterns of Molecular Defects in Dopa-Responsive Dystonia
    Article Snippet: We used nonlinear regression curve fitting in SigmaPlot (version 9.0; Systat Software, Inc., San Jose, CA) to determine the kinetic parameters for TH, wt, and mutants, using either a simple Michaelis–Menten (MM) equation or MM with substrate inhibition (Eq.).

    Article Title: The profile of mephedrone on human monoamine transporters differs from 3,4-methylenedioxymethamphetamine primarily by lower potency at the vesicular monoamine transporter.
    Article Snippet: Mephedrone (4-methylmethcathinone, MMC) and 3,4-methylenedioxymethamphetamine (MDMA) are constituents of popular party drugs with psychoactive effects.. Structurally they are amphetamine-like substances with monoamine neurotransmitter enhancing actions.. We therefore compared their effects on the human monoamine transporters using human cell lines stably expressing the human noradrenaline, dopamine and serotonin transporter (NET, DAT and SERT); preparations of synaptic vesicles from human striatum in uptake experiments; and a superfusion systemwhere releasing effects can be reliably measured.

    Article Title: Variation in Stem Xylem Traits is Related to Differentiation of Upper Limits of Tree Species along an Elevational Gradient
    Article Snippet: To test relationships between species mean values in functional traits and upper limit of species distributions, between elevations and climatic variables, we fit bivariate relationships using parametric coefficients (r2) and P-values (P), and fit lines by using linear regression or nonlinear curve fitting (SigmaPlot v12.5, Systat Software, Inc., San Jose, CA, USA).

    Inhibition:

    Article Title: Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
    Article Snippet: The measurement of the effect of new chemical entities on human UDP-glucuronosyltransferase (UGT) marker activities using in vitro experimentation represents an important experimental approach in drug development to guide clinical drug-interaction study designs or support claims that no in vivo interaction will occur.. Selective high-performance liquid chromatography-tandem mass spectrometry functional assays of authentic glucuronides for five major hepatic UGT probe substrates were developed: -estradiol3-glucuronide (UGT1A1), trifluoperazine-N-glucuronide (UGT1A4), 5-hydroxytryptophol-O-glucuronide (UGT1A6), propofol-O-glucuronide (UGT1A9), and zidovudine-5 -glucuronide (UGT2B7).. High analytical sensitivity permitted characterization of enzyme kinetic parameters at low human liver microsomal and recombinant UGT protein concentration (0.025 mg/ml), which led to a new recommended optimal universal alamethicin activation concentration of 10 g/ml for microsomes.

    Concentration Assay:

    Article Title: Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
    Article Snippet: The measurement of the effect of new chemical entities on human UDP-glucuronosyltransferase (UGT) marker activities using in vitro experimentation represents an important experimental approach in drug development to guide clinical drug-interaction study designs or support claims that no in vivo interaction will occur.. Selective high-performance liquid chromatography-tandem mass spectrometry functional assays of authentic glucuronides for five major hepatic UGT probe substrates were developed: -estradiol3-glucuronide (UGT1A1), trifluoperazine-N-glucuronide (UGT1A4), 5-hydroxytryptophol-O-glucuronide (UGT1A6), propofol-O-glucuronide (UGT1A9), and zidovudine-5 -glucuronide (UGT2B7).. High analytical sensitivity permitted characterization of enzyme kinetic parameters at low human liver microsomal and recombinant UGT protein concentration (0.025 mg/ml), which led to a new recommended optimal universal alamethicin activation concentration of 10 g/ml for microsomes.

    Control:

    Article Title: Optimized assays for human UDP-glucuronosyltransferase (UGT) activities: altered alamethicin concentration and utility to screen for UGT inhibitors.
    Article Snippet: The measurement of the effect of new chemical entities on human UDP-glucuronosyltransferase (UGT) marker activities using in vitro experimentation represents an important experimental approach in drug development to guide clinical drug-interaction study designs or support claims that no in vivo interaction will occur.. Selective high-performance liquid chromatography-tandem mass spectrometry functional assays of authentic glucuronides for five major hepatic UGT probe substrates were developed: -estradiol3-glucuronide (UGT1A1), trifluoperazine-N-glucuronide (UGT1A4), 5-hydroxytryptophol-O-glucuronide (UGT1A6), propofol-O-glucuronide (UGT1A9), and zidovudine-5 -glucuronide (UGT2B7).. High analytical sensitivity permitted characterization of enzyme kinetic parameters at low human liver microsomal and recombinant UGT protein concentration (0.025 mg/ml), which led to a new recommended optimal universal alamethicin activation concentration of 10 g/ml for microsomes.

    Software:

    Article Title: Tracing the Influence of Manure as a Complex Mixture on the Soil Sorption of Pharmaceuticals Back to Selected Chemical Constituents
    Article Snippet: .. KOC = Kd / OC (%) × 100 . (3) Curve fitting by nonlinear regression was done using the SigmaPlot 14 software (Systat GmbH, Frankfurt/Main, Germany). ..



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